Tumour suppression by blocking palmitoylation

Stephane Lefrancois (1)

1 INRS-IAF - Institut Armand Frappier

Enhanced lysosomal degradation of the transmembrane protein programmed cell-death protein-1 ligand in tumour cells, enabled by blocking the protein’s post-translational lipid modification, promotes T-cell-mediated suppression of tumour growth in mice.

Domaines: Cancer

Stephane Lefrancois. Tumour suppression by blocking palmitoylation. Nature Biomedical Engineering, 2019, 3 (4), pp.255-256. ⟨10.1038/s41551-019-0383-6⟩. ⟨pasteur-02133023⟩