Skip to Main content Skip to Navigation
New interface
Journal articles

Reduced prevalence of alcoholic gastritis in hospitalized individuals who consume cannabis

Abstract : BACKGROUND: Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co-used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users. METHODS: We analyzed hospital discharge records of adults (age ≥ 18 years), from 2014 of the Nationwide Inpatient Sample, with a diagnosis of risky alcohol use (n = 316,916). We used a propensity-based matching algorithm to match cannabis users to nonusers on 1:1 ratio (30,713: 30,713). We then measured the adjusted relative risk (aRR) for having alcoholic gastritis using conditional Poisson regression models with generalized estimating equations. RESULTS: Our study revealed that among risky alcohol users, cannabis co-users have a lower prevalence of alcoholic gastritis compared to noncannabis users (1,289 [1,169 to 1,421] vs. 1,723 [1,583 to 1,875] per 100,000 hospitalizations for risky alcohol use), resulting in a 25% decreased probability of alcoholic gastritis (aRR: 0.75 [0.66 to 0.85]; p-value <0.0001). Furthermore, dependent cannabis usage resulted in a lower prevalence of alcoholic gastritis when compared to both nondependent cannabis users (0.72 [0.52 to 0.99]) and to noncannabis users (0.56 [0.41 to 0.76]). CONCLUSIONS: We reveal that risky alcohol drinking combined with cannabis use is associated with reduced prevalence of alcohol-associated gastritis in patients. Given increased cannabis legislation globally, understanding whether and how the specific ingredients in cannabis plant extract can be used in the treatment of alcoholic gastritis is paramount. In this regard, further molecular mechanistic studies are needed to delineate the mechanisms of our novel findings not only for alcoholic gastritis but also for gastritis from other causes.
Document type :
Journal articles
Complete list of metadata
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, May 17, 2019 - 8:36:39 PM
Last modification on : Tuesday, August 6, 2019 - 11:39:21 AM

Links full text




Adeyinka Charles Adejumo, Jingjing Li, Olalekan Akanbi, Kelechi Lauretta Adejumo, Terence Ndonyi Bukong. Reduced prevalence of alcoholic gastritis in hospitalized individuals who consume cannabis. Alcoholism: Clinical and Experimental Research, 2019, 43 (2), pp.270-276. ⟨10.1111/acer.13930⟩. ⟨pasteur-02133241⟩



Record views