Development of novel treatments for hepatitis C. Lancet Infect Dis, vol.9, p.19179226, 2009. ,
Replication of hepatitis C virus, Nat Rev Microbiol, vol.5, issue.6, pp.453-63, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00313684
Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase, J Virol, vol.76, issue.8, p.136118, 2002. ,
Replication of hepatitis C virus RNA on autophagosomal membranes, J Biol Chem, vol.287, issue.22, p.3365724, 2012. ,
Rapid development of hepatic alpha1-antitrypsin globules after liver transplantation for chronic hepatitis C, Gastroenterology, vol.112, issue.4, pp.1372-1377, 1997. ,
, At 48hr post transfection, immunofluorescence images were taken for ATG4BDN (red) and nucleus (blue). Scale bar, 10?m. E. Infected Huh7 cells (>90% infected) were either mock-transfected (empty plasmid) or transfected with pmStrawberry-ATG4BC74A (ATG4B-DN). Transfected cells were stained for NS3 as described in materials and methods then analyzed by flow cytometry at 72 h post-transfection for NS3 expression gating on red-fluorescent cells (pmStrawberry-ATG4B-DN positive cells). F. Huh7 cells were either transfected with an empty plasmid (mock) or a plasmid encoding a conjugationdefective dominant negative form of ATG5 (ATG5-DN) or ATG12 (ATG12-DN) tagged with HA or Flag respectively. Cell lysates were analyzed by Western blot at 72 h post-transfection for elongation complex formation, ATG5-12 conjugation but not LC3-II formation is important for the HCV lifecycle. A. Huh7 cells were either transfected with an empty plasmid (mock) or a plasmid encoding an enzymatically inactive dominant negative form of ATG4B (ATG4B-DN), vol.10
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication, PLoS Pathog, vol.8, issue.12, p.3516559, 2012. ,
HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication, PLoS Pathog, vol.13, issue.9, p.5621699, 2017. ,
Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication, J Virol, p.5625520, 2017. ,
Autophagy as a regulated pathway of cellular degradation, Science, vol.290, issue.5497, p.2732363, 2000. ,
Modulation of pathogen recognition by autophagy, Front Immunol, vol.3, p.3342359, 2012. ,
Autophagy in regulation of Toll-like receptor signaling, Cell Signal, vol.24, issue.6, p.22333395, 2012. ,
Subversion of cellular autophagosomal machinery by RNA viruses, PLoS Biol, vol.3, issue.5, p.1084330, 2005. ,
Autophagy is involved in the early step of Japanese encephalitis virus infection, Microbes Infect, vol.14, issue.2, p.21946213, 2012. ,
Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication, J Biol Chem, vol.286, issue.25, p.3121359, 2011. ,
Dengue virus-induced autophagy regulates lipid metabolism, Cell Host Microbe, vol.8, issue.5, p.3026642, 2010. ,
Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells, Virology, vol.429, issue.2, p.22564420, 2012. ,
Hepatitis C virus genotype 1a growth and induction of autophagy, J Virol, vol.82, issue.5, p.2258951, 2008. ,
The autophagy machinery is required to initiate hepatitis C virus replication, Proc Natl Acad Sci U S A, vol.106, issue.33, p.2729017, 2009. ,
Autophagy proteins promote hepatitis C virus replication, Autophagy, vol.5, issue.8, pp.1224-1229, 2009. ,
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles, Autophagy, vol.5, issue.7, pp.937-982, 2009. ,
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response, Hepatology, vol.48, issue.4, p.2562598, 2008. ,
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro, J Clin Invest, vol.121, issue.1, p.3007134, 2011. ,
Hepatitis C virus-induced autophagy is independent of the unfolded protein response, J Virol, vol.86, p.22837205, 2012. ,
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy, J Virol, vol.85, issue.20, p.3187495, 2011. ,
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes, Hepatology, vol.53, issue.2, p.21274862, 2010. ,
Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling, J Virol, vol.86, issue.16, p.3421755, 2012. ,
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy, Autophagy, vol.9, issue.2, p.3552882, 2013. ,
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection, Virology, vol.405, issue.1, p.20580051, 2010. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00819569
The autophagy elongation complex (ATG5-12/16L1) positively regulates HCV replication and is required for wild-type membranous web formation, Sci Rep, vol.7, p.5220323, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01535064
Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, Nat Struct Mol Biol, vol.20, issue.4, p.23503366, 2013. ,
LC3s hire membrane breakers to attack viral shelters, Autophagy, vol.2017, p.28949789 ,
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases, Cell Host Microbe, vol.22, issue.1, p.5591033, 2017. ,
Monitoring autophagy in mammalian cultured cells through the dynamics of LC3, Methods Enzymol, vol.452, pp.1-12, 2009. ,
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis, Mol Cell, vol.44, issue.5, p.22152474, 2011. ,
Novel HCV replication mouse model using human hepatocellular carcinoma xenografts, Antiviral Res, vol.84, issue.1, pp.387-395, 2009. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00819929
, , 19622372.
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication, Antiviral Res, vol.95, issue.2, p.22626636, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00819059
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size, FEBS Lett, vol.580, issue.11, p.16647067, 2006. ,
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate, J Cell Sci, vol.116, pp.1679-88, 2003. ,
Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication, J Biol Chem, vol.285, issue.36, p.2934683, 2010. ,
Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection, J Virol, vol.88, issue.7, p.3993538, 2014. ,
Direct observation of individual endogenous protein complexes in situ by proximity ligation, Nat Methods, vol.3, issue.12, pp.995-1000, 2006. ,
Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9, J Biol Chem, vol.290, issue.38, p.4645619, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01352186
Molecular mechanism of autophagic membrane-scaffold assembly and disassembly, Cell, vol.156, issue.3, p.24485455, 2014. ,
Formation of the approximately 350-kDa Apg12-Apg5. Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast, J Biol Chem, vol.277, issue.21, p.11897782, 2002. ,
Structure of Atg5.Atg16, a complex essential for autophagy, J Biol Chem, vol.282, issue.9, p.17192262, 2007. ,
Dual Roles of Two Isoforms of Autophagyrelated Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity, Sci Rep, vol.7, issue.1, p.11250, 2017. ,
, , p.5595887
LC3 conjugation system in mammalian autophagy, Int J Biochem Cell Biol, vol.36, issue.12, p.15325588, 2004. ,
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure, Mol Biol Cell, vol.19, issue.11, p.18768752, 2008. ,
, , p.2575160
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy, Mol Biol Cell, vol.19, issue.5, p.2366860, 2008. ,
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy, J Biol Chem, vol.282, issue.52, p.17986448, 2007. ,
Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication, J Gen Virol, vol.97, issue.3, p.26727924, 2016. ,
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation, EMBO J, vol.31, issue.22, p.3501226, 2012. ,
Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation, J Virol, vol.92, issue.7, p.29367244, 2018. ,
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62, J Virol, vol.89, issue.15, p.4505648, 2015. ,
Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication, J Virol, vol.88, issue.21, p.4248894, 2014. ,
The cytotoxicity of coxsackievirus B3 is associated with a blockage of autophagic flux mediated by reduced syntaxin 17 expression, Cell Death Dis, vol.9, issue.2, p.5833838, 2018. ,
Herpes simplex virus type I induces an incomplete autophagic response in human neuroblastoma cells, J Alzheimers Dis, vol.30, issue.4, p.22475795, 2012. ,