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Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study

Claudie Laprise 1 Sreenath Arekunnath Madathil 1, 2 Nicolas Schlecht 3 Genevieve Castonguay 1 Denis Soulières 4 Phuc Felix Nguyen-Tan 4 Paul Allison 1 Francois Coutlée 4 Michael Hier 1 Marie-Claude Rousseau 2, 1 Eduardo Franco 1 Belinda Nicolau 1, *
* Corresponding author
1 McGill University = Université McGill [Montréal, Canada]
2 INRS-IAF - Institut Armand Frappier
3 Roswell Park Cancer Institute [Buffalo]
4 CHUM - Centre Hospitalier de l'Université de Montréal
Abstract : BACKGROUND: This study aimed to estimate the extent to which oral sex behavior is associated with an increased risk of oropharyngeal cancers (OPCs), and how much of the association is mediated by oral human papillomavirus (HPV) infection. METHODS: We used data from a hospital-based case-control study conducted in Montreal, Canada. Information on oral sex behaviors was collected. Oral rinse and oral brush specimens were analyzed for HPV positivity and genotyping. Logistic regression estimated the odds ratios (OR) and 95% confidence intervals (CI) for the association between oral sex behaviors and OPC. RESULTS: Onset of oral sex practice at age 16 years or younger had an increased risk of OPCs relative to those with onset after age 30 years (OR = 2.98; 95% CI 1.37-6.47). This association decreased (OR = 1.09; 95% CI 0.25-4.71) when restricted to those positive for HPV. CONCLUSIONS: Our results suggest that the association between oral sex and OPC seems mediated by oral HPV infection.
Keywords : Canada case-control study head and neck cancer human papillomavirus sexual behavior transmission
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https://hal-riip.archives-ouvertes.fr/pasteur-02136038
Contributor : Michel Courcelles <>
Submitted on : Tuesday, May 21, 2019 - 5:13:50 PM
Last modification on : Monday, July 20, 2020 - 12:33:14 PM

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Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas Schlecht, Genevieve Castonguay, Denis Soulières, et al.. Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study. Archives of Otorhinolaryngology - Head & Neck Surgery, JAMA Network- American Medical Association, 2019, 41 (3), pp.678-685. ⟨10.1002/hed.25436⟩. ⟨pasteur-02136038⟩

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