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Biological activities of interleukin (IL)-21 in human monocytes and macrophages

Abstract : The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1α and GRO-α in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages.
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https://hal-riip.archives-ouvertes.fr/pasteur-02136216
Contributor : Michel Courcelles <>
Submitted on : Tuesday, May 21, 2019 - 9:50:49 PM
Last modification on : Wednesday, May 22, 2019 - 12:02:44 PM

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Francis Vallières, Isabelle Durocher, Denis Girard. Biological activities of interleukin (IL)-21 in human monocytes and macrophages. Cellular Immunology, Elsevier, 2019, 337, pp.62-70. ⟨10.1016/j.cellimm.2019.02.002⟩. ⟨pasteur-02136216⟩

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