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Journal Articles Cell Host and Microbe Year : 2017

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

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Oscar Björnham
  • Function : Author
Yevgen Chernov
  • Function : Author
Pär Gideonsson
  • Function : Author
Sara Henriksson
  • Function : Author
Melissa Mendez
  • Function : Author
Rolf Sjöström
  • Function : Author
Anna Shevtsova
  • Function : Author
Christopher Aisenbrey
Göran Bylund
  • Function : Author
Alexej Schmidt
  • Function : Author
Anna Åberg
  • Function : Author
Lena Rakhimova
  • Function : Author
Anders Hofer
  • Function : Author
Johan Ögren
  • Function : Author
Jörgen Ådén
  • Function : Author
Magnus Unemo
  • Function : Author
  • PersonId : 895345
Stefan Oscarson
Anders Olofsson
  • Function : Author
Anders Esberg
  • Function : Author
Staffan Schedin
  • Function : Author
Anna Arnqvist
  • Function : Author
Thomas Borén
  • Function : Correspondent author
  • PersonId : 1051483

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Abstract

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Dates and versions

pasteur-02195957 , version 1 (26-07-2019)

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Cite

Jeanna Bugaytsova, Oscar Björnham, Yevgen Chernov, Pär Gideonsson, Sara Henriksson, et al.. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host and Microbe, 2017, 21 (3), pp.376-389. ⟨10.1016/j.chom.2017.02.013⟩. ⟨pasteur-02195957⟩
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