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Journal Articles Journal of General Virology Year : 2005

A novel homologue of Human herpesvirus 6 in chimpanzees

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Abstract

Among the Betaherpesvirinae, human cytomegalovirus is the only virus to possess simian homologues. Indeed, intriguingly, no close simian homologue of the roseoloviruses Human herpesvirus 6 (HHV-6) and Human herpesvirus 7 (HHV-7), the other two human members of the Betaherpesvirinae, has been identified to date. Here, the first simian homologue of HHV-6 is described, which was identified in common chimpanzees and designated PanHV6. By using a degenerate consensus PCR method, three different gene fragments were amplified, corresponding to the DNA polymerase (U38), beta-chemokine receptor (U12) and viral transactivator (U42) genes, with 94-96 % (nucleotide) and 95-97 % (amino acid) sequence identity to the corresponding genes of HHV-6B. Analysis of 77 predominantly wild-caught chimpanzees identified a unique PanHV6 strain in 21 animals, with no viral sequence variation between the different chimpanzee subspecies that were found to be infected. Characterization of this virus represents a great potential to gain a better understanding of the diseases associated with HHV-6.

Dates and versions

pasteur-02197612 , version 1 (30-07-2019)

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Vincent Lacoste, Ernst J Verschoor, Eric Nerrienet, Antoine Gessain. A novel homologue of Human herpesvirus 6 in chimpanzees. Journal of General Virology, 2005, 86 (8), pp.2135-2140. ⟨10.1099/vir.0.81034-0⟩. ⟨pasteur-02197612⟩
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