HIV-1 Genetic Diversity and Drug Resistance Mutations Among Treatment-Naive Adult Patients in Suriname

Firoz Abdoel Wahid (1) , Rachel Sno (2) , Edith Darcissac (3) , Anne Lavergne (3) , Malti Adhin (4) , Vincent Lacoste (3)

1 Ministry of Health [Paramaribo, Suriname]
2 MWI - Institute for biomedical science - Medisch Wetenschappelijk Instituut [Paramaribo, Surimane]
3 Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française]
4 UVS - Anton de Kom Universiteit van Suriname - Anton de Kom University of Suriname [Paramaribo]

The molecular epidemiologic profile of HIV-1 in Suriname was determined through protease (PR) and reverse transcriptase (RT) sequences obtained from HIV-1 strains collected from 100 drug-naive HIV-1-infected persons. Subtype determination revealed that most viruses were of subtype B (94.9%) in both PR and RT genomic regions, followed by B/D recombinants (5.1%). Analysis of drug resistance mutations showed only one transmitted dug resistance mutation (TDRM) (V75M) in a single strain. The genetic data obtained can serve as a baseline for Suriname to monitor emerging mutations. This study reveals that the HIV-1 epidemic in Suriname is still characterized by a low TDRM rate (1%) and a low level of subtype diversity. However, both genes display a high genetic polymorphism. This high polymorphism may ultimately lead to drug resistance. Continuous monitoring of the baseline resistance is therefore a prerequisite to safeguard effective long-term treatment for people living with HIV-1 in Suriname.

Keywords: drug resistance mutations; Suriname; HIV genotyping

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Firoz Abdoel Wahid, Rachel Sno, Edith Darcissac, Anne Lavergne, Malti Adhin, et al.. HIV-1 Genetic Diversity and Drug Resistance Mutations Among Treatment-Naive Adult Patients in Suriname. AIDS Research and Human Retroviruses, 2016, 32 (12), pp.1223-1228. ⟨10.1089/AID.2016.0161⟩. ⟨pasteur-02197614⟩