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Journal articles
HIV-1 Genetic Diversity and Drug Resistance Mutations Among Treatment-Naive Adult Patients in Suriname
Abstract : The molecular epidemiologic profile of HIV-1 in Suriname was determined through protease (PR) and reverse transcriptase (RT) sequences obtained from HIV-1 strains collected from 100 drug-naive HIV-1-infected persons. Subtype determination revealed that most viruses were of subtype B (94.9%) in both PR and RT genomic regions, followed by B/D recombinants (5.1%). Analysis of drug resistance mutations showed only one transmitted dug resistance mutation (TDRM) (V75M) in a single strain. The genetic data obtained can serve as a baseline for Suriname to monitor emerging mutations. This study reveals that the HIV-1 epidemic in Suriname is still characterized by a low TDRM rate (1%) and a low level of subtype diversity. However, both genes display a high genetic polymorphism. This high polymorphism may ultimately lead to drug resistance. Continuous monitoring of the baseline resistance is therefore a prerequisite to safeguard effective long-term treatment for people living with HIV-1 in Suriname.
https://hal-riip.archives-ouvertes.fr/pasteur-02197614
Contributor : Vincent Lacoste Connect in order to contact the contributor
Submitted on : Monday, April 6, 2020 - 4:14:30 PM
Last modification on : Friday, October 16, 2020 - 10:16:02 AM
Contributor : Vincent Lacoste Connect in order to contact the contributor
Submitted on : Monday, April 6, 2020 - 4:14:30 PM
Last modification on : Friday, October 16, 2020 - 10:16:02 AM
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HIV-1 Genetic Diversity and Dr...
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