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Kaposi's sarcoma-associated herpesvirus immediate early gene activity

Abstract : KSHV is the causative agent of three human proliferative disorders: Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral gene transcription. The immediate early genes generally code for transcriptional activators and are critical for initiating viral transcription. KSHV encodes for approximately nine immediate early gene products, including ORF50, K8, K9, K3, K5, ORF57, ORF29b, ORF45, and K4.2. This review will address the activities of these proteins and what roles they play in virus replication, evasion of the host immune response, and viral pathogenesis.
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Contributor : Vincent Lacoste Connect in order to contact the contributor
Submitted on : Tuesday, July 30, 2019 - 3:06:41 PM
Last modification on : Thursday, July 29, 2021 - 11:38:03 AM




Vincent Lacoste, Cynthia de La Fuente, Fatah F. Kashanchi, Anne Pumfery. Kaposi's sarcoma-associated herpesvirus immediate early gene activity. Frontiers in Bioscience, 2004, 9 (1-3), pp.2245-2272. ⟨10.2741/1394⟩. ⟨pasteur-02197625⟩



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