Molecular characterization of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia

Abstract : We report the molecular characterization, with subtyping of both K1 and K14.1/K15 genomic regions, of seven new human herpesvirus-8 (HHV-8) strains from Russian patients with classical Kaposi's sarcoma. Phylogenetic studies, based on the complete K1 gene/protein analysis, indicate that six of these strains belong to the A subtype, with one belonging to the A4 group and exhibiting a unique deletion of 19 amino acids in the VR2 region at position 186-204. PCR-based studies of the K14.1/K15 genomic region indicate that four of the new strains were of the M subtype while three belonged to the P subtype. Our study indicates an important genetic diversity of the HHV-8 strains currently present in Russia, including a new peculiar strain possessing a unique deletion in the VR2 segment, and confirms the absence of correlation between the K1 and K14.1/K15 molecular subtypes, as M and P genotypes can be observed in the A K1 subtype.
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Contributor : Vincent Lacoste <>
Submitted on : Tuesday, July 30, 2019 - 3:20:48 PM
Last modification on : Friday, August 2, 2019 - 2:15:50 AM

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Vincent Lacoste, Elena Kadyrova, Irina Chistiakova, Vladimir Gurtsevitch, Jean-Gabriel Judde, et al.. Molecular characterization of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia. Journal of General Virology, Microbiology Society, 2000, 81 (5), pp.1217-1222. ⟨10.1099/0022-1317-81-5-1217⟩. ⟨pasteur-02197662⟩

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