Label-free cocaine aptasensor based on a long-period fiber grating

Anna Celebanska; Yasser Chiniforooshan; Monika Janik; Predrag Mikulic; Balasubramanian Sellamuthu; Ryan Walsh; Jonathan Perreault; Wojtek Bock

doi:10.1364/OL.44.002482

Journal articles

Label-free cocaine aptasensor based on a long-period fiber grating

Anna Celebanska ^{1, *} Yasser Chiniforooshan ¹ Monika Janik ¹ Predrag Mikulic ¹ Balasubramanian Sellamuthu ^{2, 3} Ryan Walsh ³ Jonathan Perreault ³ Wojtek Bock ¹

* Corresponding author

1 CRP - Centre de Recherche en Photonique [UQO, Gatineau, Québec, Canada]

UQO - Université du Québec en Outaouais

2 CHUM - Centre Hospitalier de l'Université de Montréal

3 INRS-IAF - Institut Armand Frappier

Abstract : In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 μM. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal-riip.archives-ouvertes.fr/pasteur-02275162
Contributor : Michel Courcelles <>
Submitted on : Friday, August 30, 2019 - 3:24:24 PM
Last modification on : Wednesday, October 14, 2020 - 4:18:17 AM

Label-free cocaine aptasensor based on a long-period fiber grating

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Label-free cocaine aptasensor based on a long-period fiber grating

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