 |
Journal articles
Label-free cocaine aptasensor based on a long-period fiber grating
Abstract : In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 μM. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device.
https://hal-riip.archives-ouvertes.fr/pasteur-02275162
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, August 30, 2019 - 3:24:24 PM
Last modification on : Wednesday, October 14, 2020 - 4:18:17 AM
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, August 30, 2019 - 3:24:24 PM
Last modification on : Wednesday, October 14, 2020 - 4:18:17 AM