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Label-free cocaine aptasensor based on a long-period fiber grating

Abstract : In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 μM. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device.
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Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, August 30, 2019 - 3:24:24 PM
Last modification on : Wednesday, October 14, 2020 - 4:18:17 AM




Anna Celebanska, Yasser Chiniforooshan, Monika Janik, Predrag Mikulic, Balasubramanian Sellamuthu, et al.. Label-free cocaine aptasensor based on a long-period fiber grating. Optics Letters, 2019, 44 (10), pp.2482. ⟨10.1364/OL.44.002482⟩. ⟨pasteur-02275162⟩



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