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Revealing Drug Self-Associations into Nano-Entities

Abstract : The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.
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Submitted on : Friday, August 30, 2019 - 3:46:00 PM
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Marwa Dlim, Fatma Shahout, Marwa Khabir, Patrick Labonté, Steven Laplante. Revealing Drug Self-Associations into Nano-Entities. ACS Omega, ACS Publications, 2019, 4 (5), pp.8919-8925. ⟨10.1021/acsomega.9b00667⟩. ⟨pasteur-02275234⟩

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