The influence of drug-like concepts on decision-making in medicinal chemistry, Nat. Rev. Drug Discovery, vol.6, p.881, 2007. ,
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Delivery Rev, vol.23, p.3, 1997. ,
Lead-and drug-like compounds: the rule-of-five revolution, Drug Discovery Today: Technol, vol.1, p.337, 2004. ,
Characteristic physical properties and structural fragments of marketed oral drugs, J. Med. Chem, p.224, 2004. ,
The evolution of synthetic oral drug properties, Bioorg. Med. Chem. Lett, p.1087, 2005. ,
The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds, J. Med. Chem, p.2969, 2006. ,
Property-based design: optimization of drug absorption and pharmacokinetics, J. Med. Chem, p.1313, 2001. ,
The role of hydrophobicity in toxicity prediction, Curr. Comput.-Aided Drug Des, vol.2, p.405, 2006. ,
Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety, Chem. Res. Toxicol, 1420. ,
Monitoring drug selfaggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy, J. Med. Chem, vol.56, pp.7073-7083, 2013. ,
Physiochemical drug properties associated with in vivo toxicological outcomes, Bioorg. Med. Chem. Lett, vol.18, pp.4872-4875, 2008. ,
Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists, J. Med. Chem, vol.56, pp.5142-5150, 2013. ,
Identification and prediction of promiscuous aggregating inhibitors among known drugs, J. Med. Chem, vol.46, pp.4477-4486, 2003. ,
A high-throughput screen for aggregation-based inhibition in a large compound library, J. Med. Chem, vol.50, 2007. ,
Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture, ACS Chem. Biol, vol.7, pp.1429-1435, 2012. ,
Colloidal Drug Formulations Can Explain "Bell-Shaped" Concentration?Response Curves, ACS Chem. Biol, vol.9, pp.777-784, 2014. ,
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability, J. Med. Chem, p.48, 1974. ,
Colloidal aggregation: From screening nuisance to formulation nuance, Nano Today, vol.19, 2018. ,
Molecular imaging of intracellular drug?membrane aggregate formation, Macromolecules, vol.44, 1742. ,
Clofazimine binding studies with deoxyribonucleic acid, Int J Lepr Other Mycobact Dis, vol.44, pp.475-481, 1976. ,
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity, Bioorg. Med. Chem. Lett, p.1140, 2015. ,
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127), J. Med. Chem, p.1845, 2013. ,