Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease

Abstract : Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine (CML) and pentosidine were found in the brain from Alzheimer's disease (AD) patients and were associated with the neuropathological hallmarks of AD. In AD patients, the circulating level of both AGEs remains unknown. Moreover, their levels in peripheral extracellular vesicles (EVs) and their association with AD remain to be determined. Finally, it is not known if neuronal cells can release AGEs via EVs and propagate AGEs.
Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-02275370
Contributor : Michel Courcelles <>
Submitted on : Friday, August 30, 2019 - 4:29:21 PM
Last modification on : Tuesday, September 3, 2019 - 6:03:15 PM

Identifiers

Collections

Citation

Mohamed Haddad, Morgane Perrotte, Sarra Landri, Aurelie Lepage, Tamas Fulöp, et al.. Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease. Journal of Alzheimer's Disease, IOS Press, 2019, 69 (3), pp.751-762. ⟨10.3233/JAD-181272⟩. ⟨pasteur-02275370⟩

Share

Metrics

Record views

4