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Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease

Mohamed Haddad 1, 2 Morgane Perrotte 1, 2 Sarra Landri 1, 2 Aurelie Lepage 3 Tamas Fulöp 3 Charles Ramassamy 2, 1, *
* Corresponding author
1 INRS-IAF - Institut Armand Frappier
2 INAF - Institut sur la Nutrition et les Aliments Fonctionnels [université Laval, Québec]
3 CSSS-IUGS - Centre de Recherche sur le Vieillissement
Abstract : Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine (CML) and pentosidine were found in the brain from Alzheimer's disease (AD) patients and were associated with the neuropathological hallmarks of AD. In AD patients, the circulating level of both AGEs remains unknown. Moreover, their levels in peripheral extracellular vesicles (EVs) and their association with AD remain to be determined. Finally, it is not known if neuronal cells can release AGEs via EVs and propagate AGEs.
Keywords : Alzheimer’s disease Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) carboxymethyl lysine (CML) extracellular vesicles pentosidine
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https://hal-riip.archives-ouvertes.fr/pasteur-02275370
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Submitted on : Friday, August 30, 2019 - 4:29:21 PM
Last modification on : Thursday, April 29, 2021 - 3:10:03 PM

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Mohamed Haddad, Morgane Perrotte, Sarra Landri, Aurelie Lepage, Tamas Fulöp, et al.. Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease. Journal of Alzheimer's Disease, IOS Press, 2019, 69 (3), pp.751-762. ⟨10.3233/JAD-181272⟩. ⟨pasteur-02275370⟩

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