Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease - Archive ouverte HAL Access content directly
Journal Articles Journal of Alzheimer's Disease Year : 2019

Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease

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Abstract

Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine (CML) and pentosidine were found in the brain from Alzheimer's disease (AD) patients and were associated with the neuropathological hallmarks of AD. In AD patients, the circulating level of both AGEs remains unknown. Moreover, their levels in peripheral extracellular vesicles (EVs) and their association with AD remain to be determined. Finally, it is not known if neuronal cells can release AGEs via EVs and propagate AGEs.
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pasteur-02275370 , version 1 (30-08-2019)

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Mohamed Haddad, Morgane Perrotte, Sarra Landri, Aurelie Lepage, Tamas Fulöp, et al.. Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease. Journal of Alzheimer's Disease, 2019, 69 (3), pp.751-762. ⟨10.3233/JAD-181272⟩. ⟨pasteur-02275370⟩

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