Adverse effects of BCG vaccine 1173 P2 in Iran: A meta-analysis

Saied Mostaan (1) , Bahador Yazdanpanah (2) , Rasool Moukhah (2) , Hamidreza Hozouri (2) , Manouchehr Rostami (2) , Mohsen Khorashadizadeh (3) , Javad Zerehsaz (4) , Ramin Pirhajatimahabadi (4) , Arya Saadi (5) , Hossein Khanahmad (6) , Mohammad Pooya (1)

1 Department of Molecular Biology [Tehran, Iran]
2 BCG department
3 BUMS - Birjand University of Medical Sciences [Birjand, Iran]
4 Tarbiat Modares University [Tehran]
5 Institut Pasteur d'Iran
6 MUI - Isfahan University of Medical Sciences [Iran]

Although in the last two decades the World Health Organization (WHO) has introduced tuberculosis as "a threat to global", the vaccination with the Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the only way for the prevention of this fatal infectious disease. Despite of the efficacy of BCG vaccine especially against infants' meningitis, it has still some limitations due to a variety of adverse effects. Many studies have evaluated the side effects of different strains of BCG vaccines in different countries. In Iran, some studies have been done so far to evaluate the adverse effects of 1173 P2 strain which is used for BCG vaccination. Each of these studies have used different standardization and sampling methods. This review will survey all studies that have been published about adverse effects of 1173 P2 strain of BCG vaccine in Iran using data mining methods.

Mots clés: 1173P2; Bacillus calmette-guerin; safety; side effects

Domaines: Sciences du Vivant [q-bio]; Immunologie; Vaccinologie

Saied Mostaan, Bahador Yazdanpanah, Rasool Moukhah, Hamidreza Hozouri, Manouchehr Rostami, et al.. Adverse effects of BCG vaccine 1173 P2 in Iran: A meta-analysis. Advanced Biomedical Research, 2016, 5 (1), pp.99. ⟨10.4103/2277-9175.183659⟩. ⟨pasteur-02896898⟩