Skip to Main content Skip to Navigation
Journal articles

Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017

Abstract : In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we performed a characterization of HCV genetic diversity based on demography, clinical data, and phylogenetic analysis of HCV nonstructural 5B (NS5B) sequences belonging to a large cohort of patients (n = 3,133) coming from majority part of Cambodia between September 2016 and December 2017. The phylogenetic analysis revealed that HCV genotype 1 and 6 were the most predominant and sharing equal proportions (46%). The remaining genotypes were genotype 2 (4.3%) and unclassified variants (3.6%). Among genotype 1, subtype 1b was the most prevalent subtype accounting for 94%. Within genotype 6, we observed a high degree of diversity and the most common viral subtypes were 6e (44%) and 6r (23%). This characteristic points to the longstanding history of HCV in Cambodia. Geographic specificity of viral genotype was not observed. Risks of HCV infection were mainly associated with experience of an invasive medical procedure (64.7%), having partner with HCV (19.5%), and blood transfusion (9.9%). In addition, all of these factors were comparable among different HCV genotypes. All these features define the specificity of HCV epidemiology in Cambodia.
Document type :
Journal articles
Complete list of metadata

https://hal-riip.archives-ouvertes.fr/pasteur-03214748
Contributor : Philippe Dussart <>
Submitted on : Sunday, May 2, 2021 - 7:07:26 PM
Last modification on : Monday, June 7, 2021 - 4:47:40 PM

File

Nouhin et al. - 2019 - Molecul...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Janin Nouhin, Momoko Iwamoto, Sophearot Prak, Jean-Philippe Dousset, Kerya Phon, et al.. Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.7314. ⟨10.1038/s41598-019-43785-4⟩. ⟨pasteur-03214748⟩

Share

Metrics

Record views

9

Files downloads

3