Airborne dust and high temperatures are risk factors for invasive bacterial disease - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Journal of Allergy and Clinical Immunology Année : 2017

Airborne dust and high temperatures are risk factors for invasive bacterial disease

Résumé

Background The Sahel region of West Africa has the highest bacterial meningitis attack and case fatality rate in the world. The effect of climatic factors on patterns of invasive respiratory bacterial disease is not well documented. Objective We aimed to assess the link between climatic factors and occurrence of invasive respiratory bacterial disease in a Sahel region of Niger. Methods We conducted daily disease surveillance and climatic monitoring over an 8-year period between January 1, 2003, and December 31, 2010, in Niamey, Niger, to determine risk factors for bacterial meningitis and invasive bacterial disease. We investigated the mechanistic effects of these factors on Streptococcus pneumoniae infection in mice. Results High temperatures and low visibility (resulting from high concentrations of airborne dust) were identified as significant risk factors for bacterial meningitis. Dust inhalation or exposure to high temperatures promoted progression of stable asymptomatic pneumococcal nasopharyngeal carriage to pneumonia and invasive disease. Dust exposure significantly reduced phagocyte-mediated bacterial killing, and exposure to high temperatures increased release of the key pneumococcal toxin pneumolysin through increased bacterial autolysis. Conclusion Our findings show that climatic factors can have a substantial influence on infectious disease patterns, altering density of pneumococcal nasopharyngeal carriage, reducing phagocytic killing, and resulting in increased inflammation and tissue damage and consequent invasiveness. Climatic surveillance should be used to forecast invasive bacterial disease epidemics, and simple control measures to reduce particulate inhalation might reduce the incidence of invasive bacterial disease in regions of the world exposed to high temperatures and increased airborne dust.
Fichier principal
Vignette du fichier
1-s2.0-S0091674916306169-main.pdf (2.15 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

pasteur-03238492 , version 1 (27-05-2021)

Licence

Paternité

Identifiants

Citer

Jean-François Jusot, Daniel R. Neill, Elaine M. Waters, Mathieu Bangert, Marisol Collins, et al.. Airborne dust and high temperatures are risk factors for invasive bacterial disease. Journal of Allergy and Clinical Immunology, 2017, 139 (3), pp.977-986.e2. ⟨10.1016/j.jaci.2016.04.062⟩. ⟨pasteur-03238492⟩

Collections

RIIP RIIP_CERMES
17 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More