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Public Health Impact After the Introduction of PsA-TT: The First 4 Years

Abstract : Background. During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010–2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated. Methods. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence. Results. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics. Conclusions. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.
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Submitted on : Thursday, May 27, 2021 - 10:33:19 AM
Last modification on : Thursday, June 24, 2021 - 3:03:08 AM
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Fabien V. K. Diomandé, Mamoudou H. Djingarey, Doumagoum M. Daugla, Ryan T. Novak, Paul A. Kristiansen, et al.. Public Health Impact After the Introduction of PsA-TT: The First 4 Years. Clinical Infectious Diseases, Oxford University Press (OUP), 2015, 61 (suppl_5), pp.S467-S472. ⟨10.1093/cid/civ499⟩. ⟨pasteur-03238511⟩



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