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Journal articles
Public Health Impact After the Introduction of PsA-TT: The First 4 Years
Abstract : Background. During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010–2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated.
Methods. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence.
Results. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics.
Conclusions. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.
https://hal-riip.archives-ouvertes.fr/pasteur-03238511
Contributor : Jean-Marc Collard <>
Submitted on : Thursday, May 27, 2021 - 10:33:19 AM
Last modification on : Thursday, June 24, 2021 - 3:03:08 AM
Contributor : Jean-Marc Collard <>
Submitted on : Thursday, May 27, 2021 - 10:33:19 AM
Last modification on : Thursday, June 24, 2021 - 3:03:08 AM
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