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Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae

Abstract : Serotype 1 Streptococcus pneumoniae is a leading cause of invasive pneumococcal disease (IPD) worldwide, with the highest burden in developing countries. We report the whole-genome sequencing analysis of 448 serotype 1 isolates from 27 countries worldwide (including 11 in Africa). The global serotype 1 population shows a strong phylogeographic structure at the continental level, and within Africa there is further region-specific structure. Our results demonstrate that region-specific diversification within Africa has been driven by limited cross-region transfer events, genetic recombination and antimicrobial selective pressure. Clonal replacement of the dominant serotype 1 clones circulating within regions is uncommon; however, here we report on the accessory gene content that has contributed to a rare clonal replacement event of ST3081 with ST618 as the dominant cause of IPD in the Gambia.
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Contributor : Jean-Marc Collard Connect in order to contact the contributor
Submitted on : Thursday, May 27, 2021 - 10:34:09 AM
Last modification on : Tuesday, September 28, 2021 - 2:48:04 PM
Long-term archiving on: : Saturday, August 28, 2021 - 6:29:03 PM


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Jennifer E. Cornick, Chrispin Chaguza, Simon R. Harris, Feyruz Yalcin, Madikay Senghore, et al.. Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae. Microbial Genomics, Society for General Microbiology, 2015, 1 (2), pp.e000027. ⟨10.1099/mgen.0.000027⟩. ⟨pasteur-03238516⟩



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