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Molecular Epidemiology of Rabies in Wild Canidae in Tunisia

Abstract : Rabies is a viral zoonosis that is transmissible to humans via domestic and wild animals. There are two epidemiological cycles for rabies, the urban and the sylvatic cycles. In an attempt to study the epidemiological role of wild canidae in rabies transmission, the present study aimed to analyze the genetic characteristics of virus isolates and confirm prior suggestions that rabies is maintained through a dog reservoir in Tunisia. Virus strains isolated from wild canidae were subject to viral sequencing, and Bayesian phylogenetic analysis was performed using Beast2 software. Essentially, the virus strains isolated from wild canidae belonged to the Africa-1 clade, which clearly diverges from fox-related strains. Our study also demonstrated that genetic characteristics of the virus isolates were not as distinct as could be expected if a wild reservoir had already existed. On the contrary, the geographic landscape is responsible for the genetic diversity of the virus. The landscape itself could have also acted as a natural barrier to the spread of the virus.
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https://hal-riip.archives-ouvertes.fr/pasteur-03545143
Contributor : Abdelhakim Ben Hassine Connect in order to contact the contributor
Submitted on : Thursday, January 27, 2022 - 9:55:12 AM
Last modification on : Thursday, January 27, 2022 - 5:32:49 PM

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Zied Bouslama, Habib Kharmachi, Nourhene Basdouri, Jihen Ben Salem, Samia Ben Maiez, et al.. Molecular Epidemiology of Rabies in Wild Canidae in Tunisia. Viruses, MDPI, 2021, 13 (12), pp.2473. ⟨10.3390/v13122473⟩. ⟨pasteur-03545143⟩

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