HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging

Abstract : Aging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology.
Document type :
Journal articles
Complete list of metadata

https://hal-riip.archives-ouvertes.fr/pasteur-03561272
Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Tuesday, February 8, 2022 - 10:33:00 AM
Last modification on : Wednesday, February 9, 2022 - 4:17:53 PM
Long-term archiving on: : Monday, May 9, 2022 - 6:32:58 PM

File

mama9.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Marie Strickland, Besma Yacoubi-Loueslati, Balkiss Bouhaouala-Zahar, Sylvia Pender, Anis Larbi. Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging. Frontiers in Physiology, Frontiers, 2019, 10, pp.158. ⟨10.3389/fphys.2019.00158⟩. ⟨pasteur-03561272⟩

Share

Metrics

Record views

4

Files downloads

2