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A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Abstract : Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.
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Submitted on : Wednesday, February 16, 2022 - 6:12:27 AM
Last modification on : Wednesday, September 28, 2022 - 4:20:12 PM
Long-term archiving on: : Tuesday, May 17, 2022 - 6:09:43 PM

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Deborah Delaune, Vibol Hul, Erik A. Karlsson, Alexandre A. Hassanin, Tey Putita Ou, et al.. A novel SARS-CoV-2 related coronavirus in bats from Cambodia. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6563. ⟨10.1038/s41467-021-26809-4⟩. ⟨pasteur-03576361⟩

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