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A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Deborah Delaune 1, 2, 3 Vibol Hul 4 Erik Karlsson 4, 5 Alexandre Hassanin 6 Tey Putita Ou 4 Artem Baidaliuk 1 Fabiana Gámbaro 1, 7 Matthieu Prot 1 Vuong Tan Tu 6 Sokha Chea 8 Lucy Keatts 9, 10 Jonna Mazet 10 Christine Johnson 10 Philippe Buchy 4 Philippe Dussart 4 Tracey Goldstein 10 Etienne Simon-Loriere 1, * Veasna Duong 4, *
* Corresponding author
1 Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses
2 IRBA - Institut de Recherche Biomédicale des Armées
3 Université Paris-Saclay
4 Unité de Virologie / Virology Unit [Phnom Penh]
5 UVE - Unité des Virus Emergents
6 ISYEB - Institut de Systématique, Evolution, Biodiversité
7 UPC - Université Paris Cité
8 Wildlife Conservation Society [Phnom Penh, Cambodia]
9 WCS - Wildlife Conservation Society
10 UC Davis - University of California [Davis]
Abstract : Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.
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https://hal-riip.archives-ouvertes.fr/pasteur-03576361
Contributor : Philippe Dussart Connect in order to contact the contributor
Submitted on : Wednesday, February 16, 2022 - 6:12:27 AM
Last modification on : Thursday, April 7, 2022 - 1:58:36 PM
Long-term archiving on: : Tuesday, May 17, 2022 - 6:09:43 PM

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RIIP | RIIP_CAMBODGE | PASTEUR | PSL | UNIV-AG | UNIV-AMU | MNHN | EPHE | IRD | ANR | CNRS | ISYEB | INSERM | UNIV-PARIS | SORBONNE-UNIVERSITE | SU-SCIENCES | UNIV-PARIS-SACLAY | SU-TI

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Deborah Delaune, Vibol Hul, Erik Karlsson, Alexandre Hassanin, Tey Putita Ou, et al.. A novel SARS-CoV-2 related coronavirus in bats from Cambodia. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6563. ⟨10.1038/s41467-021-26809-4⟩. ⟨pasteur-03576361⟩

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