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Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

Thomas Obadia 1, 2 Gladys Gutierrez-Bugallo 3, 4 Veasna Duong 5 Ana Nuñez 6 Rosilainy Fernandes 7 Basile Kamgang 8 Liza Hery 4 D. Jiolle 9 Célestine Atyame 10 Yann Gomard 10 Sandra Abbo 11 Uros Glavinic 12 Myrielle Dupont-Rouzeyrol 13 Nicolas Pocquet 14 Sébastien Boyer 5 Catherine Dauga 15 Marie Vazeille 15 André Yébakima 16 Michael T White 2 Constantianus Koenraadt 11 Patrick Mavingui 10 Ricardo Lourenço-De-Oliveira 7 Anubis Vega-Rua 4 Eva Veronesi 12 Gorben Pijlman 11 Christophe Paupy 9 Núria Busquets 6 Xavier de Lamballerie 17 Anna-Bella Failloux 15, * 
Abstract : First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti , and secondarily, Aedes albopictus , both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika.
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Submitted on : Wednesday, August 3, 2022 - 11:19:17 AM
Last modification on : Monday, August 8, 2022 - 10:58:21 AM


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Thomas Obadia, Gladys Gutierrez-Bugallo, Veasna Duong, Ana Nuñez, Rosilainy Fernandes, et al.. Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project. Nature Communications, Nature Publishing Group, 2022, 13 (1), pp.4490. ⟨10.1038/s41467-022-32234-y⟩. ⟨pasteur-03744692⟩



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