Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Pharmacology Year : 2023

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

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Abstract

Introduction: Formerly named Plectranthus forsteri , Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1 ), coleon U-quinone ( 2 ), 8α,9α-epoxycoleon U-quinone ( 3 ), horminone or 7α-hydroxyroyleanone ( 4 ), 6β,7α-dihydroxyroyleanone ( 5 ), 7α-acetoxy-6β-hydroxyroyleanone ( 6 ) and 7α-formyloxy-6β-hydroxyroyleanone ( 7 ). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.
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pasteur-03931609 , version 1 (09-01-2023)

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Attribution - CC BY 4.0

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Mael Nicolas, Malia Lasalo, Sharron Chow, Cyril Antheaume, Karl Huet, et al.. Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization. Frontiers in Pharmacology, 2023, 13, pp.1081310. ⟨10.3389/fphar.2022.1081310⟩. ⟨pasteur-03931609⟩
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