Multi-scale characterization of Developmental Defects of Enamel and their clinical significance for diagnosis and treatment

Sophia Houari (1, 2, 3) , Karen Derocher , Tran Thu Thuy , Thibaud Coradin (4, 5) , Vesna Srot , Peter A van Aken , Hélène Lecoq , Thierry Sauvage , Etienne Balan , Julie Aufort , Marco Calemme , Nicolas Roubier , Julia Bosco , Katia Jedeon , Ariane Berdal , Derk Joester , Sylvie Babajko

1 CRC - Inserm U1138 - Physiopathologie orale moléculaire
2 CHU Pitié-Salpêtrière [AP-HP]
3 EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales
4 LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
5 LCMCP-MATBIO - Matériaux et Biologie

properties of dental enamel teeth affected by two major DDE, Dental Fluorosis (DF) or Molar Incisor Hypomineralization (MIH). We evidence specific enamel structural and optical features for DF and MIH while chemical modifications of the mineral nanocrystals were mostly correlated with lesion severity. Our results pave the way of the concept of personalized dentistry. In the light of our results, we propose a new means of clinical diagnosis for an adapted and improved restoration protocol for these patients.

Keywords: Developmental Defect of Enamel Crystallography Electron microscopy Nuclear techniques Atom Probe Tomography

Domains: Life Sciences [q-bio]

Sophia Houari, Karen Derocher, Tran Thu Thuy, Thibaud Coradin, Vesna Srot, et al.. Multi-scale characterization of Developmental Defects of Enamel and their clinical significance for diagnosis and treatment. Acta Biomaterialia, 2023, ⟨10.1016/j.actbio.2023.08.011⟩. ⟨hal-04193550⟩