Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Risk factors for acquisition of meningococcal carriage in the African meningitis belt

Abstract : Objective To investigate potential risk factors for acquisition in seven countries of the meningitis belt. Methods Households were followed up every 2 weeks for 2 months, then monthly for a further 4 months. Pharyngeal swabs were collected from all available household members at each visit and questionnaires completed. Risks of acquisition over the whole study period and for each visit were analysed by a series of logistic regressions. Results Over the course of the study, acquisition was higher in: (i) 5-to 14-year olds, as compared with those 30 years or older (OR 3.6, 95% CI 1.4–9.9); (ii) smokers (OR 3.6, 95% CI 0.98–13); and (iii) those exposed to wood smoke at home (OR 2.6 95% CI 1.3–5.6). The risk of acquisition from one visit to the next was higher in those reporting a sore throat during the dry season (OR 3.7, 95% CI 2.0–6.7) and lower in those reporting antibiotic use (OR 0.17, 95% CI 0.03–0.56). Conclusions Acquisition of meningococcal carriage peaked in school age children. Recent symptoms of sore throat during the dry season, but not during the rainy season, were associated with a higher risk of acquisition. Upper respiratory tract infections may be an important driver of epidemics in the meningitis belt.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-02263733
Contributor : Isabelle COMBE Connect in order to contact the contributor
Submitted on : Wednesday, June 9, 2021 - 5:53:51 PM
Last modification on : Wednesday, June 23, 2021 - 12:10:02 PM
Long-term archiving on: : Friday, September 10, 2021 - 7:16:24 PM

File

tmi.13203.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Laura V. Cooper, Anna Robson, Caroline L. Trotter, Abraham Aseffa, Jean-Marc Collard, et al.. Risk factors for acquisition of meningococcal carriage in the African meningitis belt. Tropical Medicine & International Health, John Wiley & Sons Ltd, 2019, 24 (4), pp.392-400. ⟨10.1111/tmi.13203⟩. ⟨hal-02263733⟩

Share

Metrics

Record views

86

Files downloads

30