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Potential of the mosquito Aedes malayensis as an arbovirus vector in South East Asia

Abstract : Many emerging arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and yellow fever virus (YFV) originated in sylvatic cycles and have emerged among humans through spillover transmission by mosquito species that ‘bridge’ sylvatic and human transmission cycles. These bridge vectors can also mediate ‘spillback’ transmission of arboviruses from humans into novel sylvatic cycles. This PhD focused on Aedes malayensis, a mosquito species widely distributed in South East Asia, to assess its potential as an arbovirus vector. We identified Ae. malayensis for the first time in Laos during mosquito surveys conducted in a forested area of the Nakai Nam Theun National Protected Area (NNT NPA). Using field-based human-baited traps, we found that Ae. malayensis engaged in human-biting behavior and therefore could act as bridge vector in the NNT NPA. In laboratory conditions, this sylvatic population of Ae. malayensis displayed a relatively low vector competence for DENV and YFV and a lack of detectable attraction to human odor. However, vector competence assays and a human-baited trap survey showed that a peridomestic Ae. malayensis population in Singapore was competent for YFV and engaged in contact with humans. Overall, this PhD work highlighted that ancillary vectors should not be overlooked to fully assess the risk of arbovirus emergence.
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Submitted on : Friday, February 12, 2021 - 12:23:37 PM
Last modification on : Thursday, April 7, 2022 - 10:10:44 AM
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  • HAL Id : tel-03139804, version 1


Elliott Miot. Potential of the mosquito Aedes malayensis as an arbovirus vector in South East Asia. Virology. Sorbonne Université, 2019. English. ⟨NNT : 2019SORUS548⟩. ⟨tel-03139804⟩



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