EFFECT OF PSEUDOMONAS SP. S-17 RHAMNOLIPID ON HERPES SIMPLEX VIRUS TYPE 2

Ana Ivanova (1) , Elena Karpenko (2) , Angel S. Galabov (1) , Mimi Remichkova (1)

1 Institut Stephan Angeloff
2 Lviv Institute of Physical-Organic Chemistry

Rhamnolipid PS-17 is ramnose-containing glicolipid and biosurfactant pro- duced by Pseudomonas sp. S-17. The biosurfactant activity has been deter- mined against herpes simplex virus type 2 (HSV-2) in vitro. No inactivation of virus infectivity after pretreatment with rhamnolipid PS-17 was observed. The compound in concentrations below its critical micelle concentration was found to be an active inhibitor of HSV-2 replication in Madin-Darby bovine kidney cells (MDBK). Thus, rhamnolipid PS-17 is perspective for a combined therapy of virus infections.

Keywords: herpes simplex type 2; biosurfactants; rhamnolipid

Domains: Microbiology and Parasitology

Ana Ivanova, Elena Karpenko, Angel S. Galabov, Mimi Remichkova. EFFECT OF PSEUDOMONAS SP. S-17 RHAMNOLIPID ON HERPES SIMPLEX VIRUS TYPE 2. Comptes rendus de l'Académie bulgare des Sciences, 2010, 64 (1), pp.157-160. ⟨pasteur-00748962⟩