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Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.

Abstract : : Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
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Submitted on : Tuesday, July 15, 2014 - 3:33:19 PM
Last modification on : Wednesday, April 15, 2020 - 9:58:40 AM
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Gianni Colotti, Andrea Ilari, Annarita Fiorillo, Paola Baiocco, Maria Agostina Cinellu, et al.. Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.. ChemMedChem, Wiley-VCH Verlag, 2013, epub ahead of print. ⟨10.1002/cmdc.201300276⟩. ⟨pasteur-01024027⟩

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