Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.

Gianni Colotti (1, 2) , Andrea Ilari (1, 2) , Annarita Fiorillo (1, 2) , Paola Baiocco (1, 2) , Maria Agostina Cinellu (3) , Laura Maiore (3) , Federica Scaletti (4) , Chiara Gabbiani (5) , Luigi Messori (4)

1 CNR - National Research Council of Italy -
2 Department of Biochemical Sciences "Rossi Fanelli"
3 Department of Chemistry & Pharmacy
4 Department of Chemistry
5 Departmento of Chemistry & Industrial Chemistry

: Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.

Keywords: antiprotozoal agents; gold; inhibitors; Leishmania; trypanothione reductase

Domains: Biochemistry, Molecular Biology; Parasitology

Gianni Colotti, Andrea Ilari, Annarita Fiorillo, Paola Baiocco, Maria Agostina Cinellu, et al.. Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.. ChemMedChem, 2013, epub ahead of print. ⟨10.1002/cmdc.201300276⟩. ⟨pasteur-01024027⟩