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High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis

Abstract : Leptospirosis is a severe zoonosis which immunopathogenesis is poorly understood. We evaluated correlation between acute form of the disease and the ratio of the anti-inflammatory cytokine IL-10 to the pro-inflammatory TNF-α and IL-1β expression during the early phase of infection comparing resistant mice and susceptible hamsters infected with two different species of virulent Leptospira. The IL-10/TNF-α and IL-10/IL-1β expression ratios were higher in mouse compared to hamster independently of the Leptospira strain, suggesting a preponderant role of the host response and notably these cytokines in the clinical expression and survival to leptospirosis. Using an IL-10 neutralization strategy in Leptospira-infected mouse model, we also showed evidence of a possible role of this cytokine on host susceptibility, bacterial clearance and on regulation of cytokine gene expression.
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Mariko Matsui, Roche Louise, Soupé-Gilbert Marie-Estelle, Milena Hasan, Didier Monchy, et al.. High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis. Cytokine, Elsevier, 2017, 96, pp.144-151. ⟨10.1016/j.cyto.2017.03.009⟩. ⟨pasteur-01510838⟩

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