Revealing Drug Self-Associations into Nano-Entities

Marwa Dlim (1) , Fatma Shahout (1) , Marwa Khabir (1) , Patrick Labonté (1) , Steven R. Laplante (1)

1 INRS-IAF - Institut Armand Frappier

The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Biochemistry, Molecular Biology

Marwa Dlim, Fatma Shahout, Marwa Khabir, Patrick Labonté, Steven R. Laplante. Revealing Drug Self-Associations into Nano-Entities. ACS Omega, 2019, 4 (5), pp.8919-8925. ⟨10.1021/acsomega.9b00667⟩. ⟨pasteur-02275234⟩