Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

Annika Suttie (1, 2, 3) , Erik A. Karlsson (1) , Yi-Mo Deng (3) , Srey Viseth Horm (1) , Sokhoun Yann (1) , Songha Tok (1) , San Sorn (4) , Davun Holl (4) , Sothyra Tum (4) , Aeron C. Hurt (3) , Andrew R. Greenhill (2) , Ian G. Barr (3) , Paul F. Horwood (1, 5) , Philippe Dussart (1)

1 Unité de Virologie / Virology Unit [Phnom Penh]
2 Federation University [Churchill, Australia]
3 The Peter Doherty Institute for Infection and Immunity [Melbourne]
4 Ministry of Agriculture, Forestry and Fisheries [Cambodia]
5 JCU - James Cook University

Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/ Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications.

Keywords: A(H5N1); A(H9N2); Cambodia; Influenza; Live bird markets; Reassortment

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology

Annika Suttie, Erik A. Karlsson, Yi-Mo Deng, Srey Viseth Horm, Sokhoun Yann, et al.. Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets. Virology, 2018, 523, pp.22 - 26. ⟨10.1016/j.virol.2018.07.028⟩. ⟨pasteur-03214742⟩