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MLVA-typing on Streptococcus pneumoniae serotype 1 isolated from meningitis cases in Niger before the introduction of PCV-13 revealed a low genetic diversity

Abstract : Background Serotype 1 was the most prevalent pneumococcal meningitis serotype encountered in Niger over the period 2003–2011 (pre-vaccination era), accounting for 45.3% of infections. Methods Multiple locus VNTR analysis (MLVA) was used to create a genotypic snapshot of a representative subset of the pneumococcal population of serotype 1. Results MLVA using 16 markers revealed a homogeneous genetic background of pneumococci serotype 1 from Niger, which clustered with few serotype 1 pneumococci from some African countries, while other African countries displayed different clonal complexes. DNA from Niger and from other African countries were different from pneumococci serotype 1 from European countries. Conclusions MLVA-typing revealed a low genetic diversity among pneumococci serotype 1 from meningitis cases in Niger in the pre-vaccination era.
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https://hal-riip.archives-ouvertes.fr/pasteur-03238518
Contributor : Jean-Marc Collard <>
Submitted on : Thursday, May 27, 2021 - 10:34:36 AM
Last modification on : Friday, June 25, 2021 - 3:02:45 AM

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Abdelkader Alio Sanda, Alexandra Granger Farbos, Amina Amadou Hamidou, Pascale Vonaesch, Jean-François Jusot, et al.. MLVA-typing on Streptococcus pneumoniae serotype 1 isolated from meningitis cases in Niger before the introduction of PCV-13 revealed a low genetic diversity. Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2015, 109 (7), pp.477-480. ⟨10.1093/trstmh/trv033⟩. ⟨pasteur-03238518⟩

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